When topical treatment for pyoderma fails

In a lecture at VMX, Jason B. Pieper, DVM, MS, DACVD, outlined the next steps in the treatment of pyoderma in dogs when the infection is non-responsive to topical therapy. If topical therapy for the treatment of pyoderma is not successful, the next step is empirical systemic treatment, according Jason B. Pieper, DVM, MS, DACVD, assistant professor at Iowa State University. According to his lecture Updates in pyoderma: diagnosis and treatment, presented at the 2025 Veterinary Meeting & Expo (VMX) in Orlando, Florida, systemic antibiotics are no longer the recommended first treatment of choice due to the rise in antimicrobial resistance and awareness. However, in cases where topicals have failed or cannot be used to treat a patient’s infection, systemic treatment is the next treatment of choice, followed by bacterial culture and susceptibility.1…

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