Bills vs. Jaguars 2024 Prediction, Odds, Picks – Sep 23

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The Buffalo Bills (2-0) are considered favorites (-5) according to the oddsmakers ahead of their game against the Jacksonville Jaguars (0-2) on September 23, 2024, starting at 7:30 p.m. ET, airing on ESPN. The matchup has an over/under of 45.5 points.

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